Giants 41, Browns 27
EAST RUTHERFORD, N.J. — Victor Cruz and Ahmad Bradshaw set career bests in leading New York Giants over winless Cleveland.
Cruz caught three touchdown passes from Eli Manning covering 3, 7 and 28 yards, while Bradshaw surpassed his yardage on the ground for the season with a career-high 200. He had 132 entering the game.
The Giants are 9-0 in games he has rushed for 100 yards or more.
New York (3-2) also forced three turnovers, including Chase Blackburn’s interception in the end zone midway in the fourth quarter to clinch it.
The Browns are 0-5 for the first time since their return season to the NFL in 1999.
Vikings 30, Titans 7
MINNEAPOLIS — Percy Harvin pounded his way through Tennessee's defense for one touchdown rushing and another receiving for Minnesota.
Harvin caught eight passes for 108 yards for the Vikings (4-1), who have given up a combined 33 points in winning three straight games. Christian Ponder threw his first two interceptions after 143 attempts without one, but he still finished 25 for 35 for 258 yards and two scores against the reeling Titans (1-4).
Matt Hasselbeck, starting in place of the injured Jake Locker, went 26 for 43 for 200 yards, one touchdown and one interception. Most of those gains came near the end with the outcome no longer in doubt.
49ers 45, Bills 3
SAN FRANCISCO — Alex Smith threw for a season-high 303 yards and three touchdowns, Frank Gore ran for 106 yards and a score, and San Francisco amassed a franchise-record 621 yards.
Michael Crabtree and Vernon Davis each eclipsed 100 yards receiving to back Smith, who threw TD passes of 43, 28 and 10 yards and surpassed 300 yards passing for only the third time in his career.
Rian Lindell kicked a 31-yard field goal in the first quarter before San Francisco scored the final 42 points to hand Buffalo (2-3) its second straight embarrassing loss.
Bears 41, Jaguars 3
JACKSONVILLE, Fla. — Charles Tillman and Lance Briggs returned interceptions for touchdowns — their second in six days — and Chicago used stifling defense to overwhelm Jacksonville.
The Bears (4-1) scored 38 unanswered points, including 35 in the second half, to win their third consecutive game. The streak has everything to do with defense.
Chicago has returned five interceptions for touchdowns in the last three weeks.
Tillman and Briggs returned two of the team's five interceptions for touchdowns in Monday night's 34-18 victory at Dallas. Safety Major Wright returned one the previous week against St. Louis.
The Jaguars (1-4) never recovered and played the final quarter amid a chorus of boos