The Hurricanes, who are alone atop the league standings, won their sixth consecutive game. They beat Duke for the second straight time — but only the fourth time in the 19-game series.
Miami had been 0-6 against No. 1 teams. Coach Jim Larranaga also beat a No. 1 team for the first time.
“This is a great memory,” Larranaga said.
Scott scored a season-high 25 points for the Hurricanes, and Kenny Kadji added a season-high 22. Shane Larkin had 18 points, 10 rebounds and five assists, and Durham, N.C. native Julian Gamble had 10 rebounds and four blocked shots.
Miami senior center Reggie Johnson came off the bench in his first action since being sidelined with a broken left thumb Dec. 18. He had two points and five rebounds in 16 minutes.
The Hurricanes, ranked this week for the first time in three years, improved to 8-0 at home.
Seth Curry, Tyler Thornton and Quinn Cook went a combined 1 for 29 for the Blue Devils, who shot a season-low 30 percent. Sulaimon led them with 16 points.
Duke went 4 for 23 from 3-point range, while Miami went 9 for 19 and shot 57 percent overall.
“Especially in the first couple of minutes, we got a lot of great shots,” Blue Devils forward Mason Plumlee said. “You’re going to miss some, but you have to keep shooting. The biggest mistake you can make is questioning your shot because you’re missing open shots.”
Kadji made two 3s during the Hurricanes’ first-half spurt, then capped it with a three-point play. Duke shot 22 percent in the first half, including two for 11 on 3-pointers, and trailed 42-19 at halftime.
There was no letup by the Hurricanes to start the second half. They scored the first seven points for a shocking 49-19 lead, and punctuated the drubbing with five dunks in the final 10 minutes.
“Some teams come out in the second half flat and think they have the game won,” Larkin said, “but we stayed with it with the same energy in the second half. We played great the whole game.”